A de novo designed signal peptide cleavage cassette functions in vivo.

Article

A de novo designed signal peptide cleavage cassette functions in vivo.

The Journal of biological chemistry - 25 Feb 1991

Nilsson I, von Heijne G

Abstract excerpt

Leader peptidase (Lep) is a membrane-bound enzyme of the Escherichia coli inner membrane that serves to remove signal peptides from exported proteins. Statistical and experimental studies of known signal peptides have defined a short C-terminal region that seems to provide the information for cor...

Topics

Amino Acid Sequence
Electrophoresis, Polyacrylamide Gel
Endopeptidases
Escherichia coli
Membrane Proteins
Molecular Sequence Data
Mutation
Plasmids
Protein Engineering
Protein Sorting Signals
Serine Endopeptidases

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