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Article

A de novo designed signal peptide cleavage cassette functions in vivo.

The Journal of biological chemistry - 25 Feb 1991

Nilsson I, von Heijne G

Abstract excerpt

Leader peptidase (Lep) is a membrane-bound enzyme of the Escherichia coli inner membrane that serves to remove signal peptides from exported proteins. Statistical and experimental studies of known signal peptides have defined a short C-terminal region that seems to provide the information for correct cleavage by Lep. Based on the patterns of conserved amino acids found in this region, we have designed a signal...

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PMID: 1995603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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A de novo designed signal peptide cleavage cassette functions in vivo.PMID 1995603Read ↗

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