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Article

Mapping of catalytically important domains in Escherichia coli leader peptidase.

The EMBO journal - 1 Sept 1990

Bilgin N, Lee J I, Zhu H Y, Dalbey R, von Heijne G

Abstract excerpt

Leader peptidase (Lep) is a central component of the secretory machinery of Escherichia coli, where it serves to remove signal peptides from secretory proteins. It spans the inner membrane twice with a large C-terminal domain protruding into the periplasmic space. To investigate the importance of the different structural domains for the catalytic activity, we have studied the effects of a large panel of Lep...

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Identifiers

PMID: 2202591
DOI: 10.1002/j.1460-2075.1990.tb07458.x
PMCID: PMC551978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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