Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study.

Neurology - 25 Jan 2011

Mattsson N, Zetterberg H, Bianconi S, Yanjanin N M, Fu R, Månsson J-E, Porter F D, Blennow K

Abstract excerpt

OBJECTIVE: Niemann-Pick disease type C (NPC) is an inherited disorder characterized by intracellular accumulation of lipids such as cholesterol and glycosphingolipids in endosomes and lysosomes. This accumulation induces progressive degeneration of the nervous system. NPC shows some intriguing similarities with Alzheimer disease (AD), including neurofibrillary tangles, but patients with NPC generally lack...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 1-Deoxynojirimycin
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Protein Precursor

Share to Amyloid Precursor Protein Secretases

Share to Glucosyltransferases

Share to Niemann-Pick Diseases

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21205675
DOI: 10.1212/WNL.0b013e318208f4ab
PMCID: PMC3034414

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study.PMID 21205675Read ↗

Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid Production<i>In Vivo</i>Semantic proximity Read ↗

Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.Semantic proximity Read ↗

Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels.Semantic proximity Read ↗

APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.Semantic proximity Read ↗

Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype-specific, and severity-linked alterations.Semantic proximity Read ↗

Plasma sphingolipid abnormalities in neurodegenerative diseasesSemantic proximity Read ↗

Presenilin, γ-Secretase, and the Search for Pathogenic Triggers of Alzheimer's Disease.Semantic proximity Read ↗

Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.Semantic proximity Read ↗

Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin.Semantic proximity Read ↗

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease.Semantic proximity Read ↗

γ-Secretase structure and activity are modified by alterations in its membrane localization and ambient environment.Semantic proximity Read ↗

Intramembrane proteolysis by gamma-secretase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.