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Article

A G-protein editor gates coenzyme B12 loading and is corrupted in methylmalonic aciduria.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2009

Padovani Dominique, Banerjee Ruma

Abstract excerpt

The mechanism by which docking fidelity is achieved for the multitude of cofactor-dependent enzymes is poorly understood. In this study, we demonstrate that delivery of coenzyme B(12) or 5'-deoxyadenosylcobalamin by adenosyltransferase to methylmalonyl-CoA mutase is gated by a small G protein, Me...

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Identifiers

PMID: 19955418
DOI: 10.1073/pnas.0908106106
PMCID: PMC2799806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19955418-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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