Article

Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B <sub>12</sub> delivery and repair

2023-03-23

Abstract excerpt

G-proteins function as molecular switches to power cofactor translocation and confer fidelity in metal trafficking. MMAA, a G-protein motor, together with MMAB, an adenosyltransferase, orchestrate cofactor delivery and repair of B 12 -dependent human methylmalonyl-CoA mutase (MMUT). The mechanism by which the motor assembles and moves a >1300 Da cargo, or fails in disease, are poorly understood. Herein, we report...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 870fe15a-cc0b-54a7-998f-54769c1219ed
DOI: 10.1101/2023.03.23.533963

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B <sub>12</sub> delivery and repairDOI 10.1101/2023.03.23.533963Read

Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair.Semantic proximity Read

Structures of the Human GTPase MMAA and Vitamin B12-dependent Methylmalonyl-CoA Mutase and Insight into Their Complex FormationSemantic proximity Read

Protein destabilization and loss of protein-protein interaction are fundamental mechanisms in cblA-type methylmalonic aciduria.Semantic proximity Read

Naturally occurring cobalamin (B <sub>12</sub> ) analogs can function as cofactors for human methylmalonyl-CoA mutaseSemantic proximity Read

Functional Characterization and Categorization of Missense Mutations that Cause Methylmalonyl‐ <scp>C</scp> o <scp>A</scp> Mutase ( <scp>MUT</scp> ) DeficiencySemantic proximity Read

A G-protein editor gates coenzyme B12 loading and is corrupted in methylmalonic aciduria.Semantic proximity Read

Genetic, structural, and functional analysis of mutations causing methylmalonyl-CoA epimerase deficiencySemantic proximity Read

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex.Semantic proximity Read

Molecular basis for dysfunction of some mutant forms of methylmalonyl-CoA mutase: deductions from the structure of methionine synthase.Semantic proximity Read

Molecular, biochemical, and structural analysis of a novel mutation in patients with methylmalonyl-CoA mutase deficiency.Semantic proximity Read

Spectrum and characterization of bi-allelic variants in MMAB causing cblB-type methylmalonic aciduria.Semantic proximity Read

Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B12 Trafficking.Semantic proximity Read