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Article

Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair.

Nature communications - 19 Jul 2023

Mascarenhas Romila, Ruetz Markus, Gouda Harsha, Heitman Natalie, Yaw Madeline, Banerjee Ruma

Abstract excerpt

G-proteins function as molecular switches to power cofactor translocation and confer fidelity in metal trafficking. The G-protein, MMAA, together with MMAB, an adenosyltransferase, orchestrate cofactor delivery and repair of B12-dependent human methylmalonyl-CoA mutase (MMUT). The mechanism by which the complex assembles and moves a >1300 Da cargo, or fails in disease, are poorly understood. Herein, we report the...

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PMID: 37468522
DOI: 10.1038/s41467-023-40077-4
PMCID: PMC10356863

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Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair.PMID 37468522Read ↗

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