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Article

Role of vitamin B12 on methylmalonyl-CoA mutase activity.

Journal of Zhejiang University. Science. B - 1 Jun 2012

Takahashi-Iñiguez Tóshiko, García-Hernandez Enrique, Arreguín-Espinosa Roberto, Flores María Elena

Abstract excerpt

Vitamin B(12) is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes, which have been grouped into three subfamilies depending on their cofactors. Among them, methylmalonyl-CoA mutase (MCM) has been extensively studied. This enzyme catalyzes the reversible isomerization of L-methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin (AdoCbl) as a cofactor...

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Identifiers

PMID: 22661206
DOI: 10.1631/jzus.B1100329
PMCID: PMC3370288

Genes

MMAA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of vitamin B12 on methylmalonyl-CoA mutase activity.PMID 22661206Read ↗

Naturally occurring cobalamin (B <sub>12</sub> ) analogs can function as cofactors for human methylmalonyl-CoA mutaseSemantic proximity Read ↗

Naturally occurring cobalamin (B12) analogs can function as cofactors for human methylmalonyl-CoA mutaseSemantic proximity Read ↗

Mutation and biochemical analysis of patients belonging to the cblB complementation class of vitamin B12-dependent methylmalonic aciduria.Semantic proximity Read ↗

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MeaB Is a Component of the Methylmalonyl-CoA Mutase Complex Required for Protection of the Enzyme from InactivationSemantic proximity Read ↗

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Genetic analysis of three genes causing isolated methylmalonic acidemia: identification of 21 novel allelic variants.Semantic proximity Read ↗

Molecular basis of methylmalonyl-CoA mutase apoenzyme defect in 40 European patients affected by mut(o) and mut- forms of methylmalonic acidemia: identification of 29 novel mutations in the MUT gene.Semantic proximity Read ↗

Molecular, biochemical, and structural analysis of a novel mutation in patients with methylmalonyl-CoA mutase deficiency.Semantic proximity Read ↗

Identification of the gene responsible for the <i>cblA</i> complementation group of vitamin B <sub>12</sub> -responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangementsSemantic proximity Read ↗

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