Article

Riluzole treatment paradoxically increases motoneuron excitability in ALS due to hyperactive homeostasis

2026-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Riluzole is the most commonly prescribed among the limited approved therapies for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by progressive motoneuron loss and paralysis. It is thought to act by suppressing motoneuron excitability and glutamate release, but its clinical benefits are modest and often diminish over time. We previously showed that homeostatic me...

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Literature Corpus work: 96ae28fa-4c2b-5999-a500-aa0b21f0bf09
DOI: 10.64898/2026.03.23.713695

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