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Article

Altered sensorimotor development in a transgenic mouse model of amyotrophic lateral sclerosis

1 Nov 2004

Abstract excerpt

Most neurodegenerative diseases become manifest at an adult age but abnormalities or pathological symptoms appear earlier. It is important to identify the initial mechanisms underlying such progressive neurodegenerative disease in both humans and animals. Transgenic mice expressing the familial amyotrophic lateral sclerosis (ALS)-linked mutation (G85R) in the enzyme superoxide dismutase 1 (SOD1) develop motor...

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PMID: 15548226
DOI: 10.1111/j.1460-9568.2004.03745.x

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