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Article

Role of Nav1.9 in activity-dependent axon growth in motoneurons

28 May 2012

Abstract excerpt

Spontaneous neural activity promotes axon growth in many types of developing neurons, including motoneurons. In motoneurons from a mouse model of spinal muscular atrophy (SMA), defects in axonal growth and presynaptic function correlate with a reduced frequency of spontaneous Ca(2+) transients in axons which are mediated by N-type Ca(2+) channels. To characterize the mechanisms that initiate spontaneous Ca(2+)...

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PMID: 22641814
DOI: 10.1093/hmg/dds195

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