Article
Gene responsible for deficient activity of the beta subunit of C8, the eighth component of complement, is located on mouse chromosome 4.
Immunogenetics - 1 Jan 1991
Tanaka S, Suzuki T, Sakaizumi M, Harada Y, Matsushima Y, Miyashita N, Fukumori Y, Inai S, Moriwaki K, Yonekawa H
Abstract excerpt
Sera from 73 strains of mice were tested for hemolytic activity through the classical and the alternative pathways (CP and AP) in a single radial hemolysis assay. Sera from 16 out of 45 laboratory inbred strains had no lytic activity, and Ouchterlony analysis with anti-C5 serum showed them to be C5-deficient. Sera from 2 out of 28 strains derived from wild mice also had no lytic activity, but the C5 molecule was...
Topics
- Animals
- Chromosome Mapping
- Complement C8
- Female
- Macromolecular Substances
- Male
- Mice
- Mice, Inbred Strains
- Mutation