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Article

The role of actin filaments and microtubules in hepatocyte spheroid self-assembly

1 Jan 2001

Abstract excerpt

Cultured rat hepatocytes self-assemble into three-dimensional structures or spheroids that exhibit ultrastructural characteristics of native hepatic tissue and enhanced liver-specific functions. The spheroid formation process involves cell translocation and changes in cell shape, indicative of the reorganization of the cytoskeletal elements. To elucidate the function of the cytoskeleton, hepatocytes undergoing...

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PMID: 11223949
DOI: 10.1002/1097-0169(200103)48:3<175::aid-cm1007>3.0.co;2-2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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