Human nucleus pulposus cells significantly enhanced biological properties in a coculture system with direct cell‐to‐cell contact with autologous mesenchymal stem cells

Abstract excerpt

Activated nucleus pulposus (NP) cells can be reinserted into the disc to inhibit intervertebral disc degeneration. Experimental studies in animals showed that using a coculture system with direct cell-to-cell contact with mesenchymal stem cells (MSCs) significantly upregulated the biological activity of NP cells. The purpose of this study is to determine whether this activation of NP cells by autologous MSCs is...

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