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Article

Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype.

Regenerative medicine - 1 Sept 2010

Strassburg Sandra, Richardson Stephen M, Freemont Anthony J, Hoyland Judith A

Abstract excerpt

AIMS: While mesenchymal stem cell (MSC)-based therapies for repair of the degenerate intervertebral disc (IVD) have been proposed, the interaction of MSCs with cells of the degenerate IVD has not been fully investigated. Therefore, it is unclear whether implanted MSCs would differentiate into nucleus pulposus (NP) cells and/or stimulate endogenous NP cells. Here, we investigate the differences in interaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20868326
DOI: 10.2217/rme.10.59

Genes

IVD
MSC
SOX9

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