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Article

Differentiation of Human Ligamentum Flavum Stem Cells Toward Nucleus Pulposus-Like Cells Induced by Coculture System and Hypoxia.

Spine - 15 Jun 2015

Han Xiao-Bo, Zhang Yan-Ling, Li Hai-Yin, Chen Bin, Chang Xian, Zhang Wei, Yang Kuang, Zhou Yue, Li Chang-Qing

Abstract excerpt

STUDY DESIGN: Human ligamentum flavum (LF)-derived stem cells (LFSCs) and nucleus pulposus cells (NPCs) were cocultured under normoxia or hypoxia. OBJECTIVE: To isolate and identify human LFSCs and determine whether they can differentiate into NPCs when cocultured with NPCs under hypoxia. SUMMARY OF BACKGROUND DATA: Mesenchymal stem cell (MSC)-based therapies have been proposed as a biological treatment for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25785962
DOI: 10.1097/BRS.0000000000000882
PMCID: PMC4450897

Genes

FOXF1
KRT19
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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