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Article

Clinical relevance of IL-1beta promoter polymorphisms (-1470, -511, and -31) in patients with major trauma.

Shock (Augusta, Ga.) - 1 Jun 2010

Wen Ai-Qing, Gu Wei, Wang Jun, Feng Kai, Qin Liu, Ying Chen, Zhu Pei-Fang, Wang Zheng-Guo, Jiang Jian-Xin

Abstract excerpt

Recent reports have indicated that IL-1[beta] is excessively released into the circulation during sepsis, and the expression level is closely correlated with the clinical course. Polymorphisms in the promoter region of IL-1B have been shown to affect LPS-induced IL-1[beta] transcription in vitro and IL-1[beta] plasma levels in healthy adults and to confer susceptibility to inflammatory diseases. However, it is...

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PMID: 19953002
DOI: 10.1097/SHK.0b013e3181cc0a8e

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