Article
A spinosyn-sensitive Drosophila melanogaster nicotinic acetylcholine receptor identified through chemically induced target site resistance, resistance gene identification, and heterologous expression.
Insect biochemistry and molecular biology - 1 May 2010
Watson Gerald B, Chouinard Scott W, Cook Kevin R, Geng Chaoxian, Gifford Jim M, Gustafson Gary D, Hasler James M, Larrinua Ignacio M, Letherer Ted J, Mitchell Jon C, Pak William L, Salgado Vincent L, Sparks Thomas C, Stilwell Geoff E
Abstract excerpt
Strains of Drosophila melanogaster with resistance to the insecticides spinosyn A, spinosad, and spinetoram were produced by chemical mutagenesis. These spinosyn-resistant strains were not cross-resistant to other insecticides. The two strains that were initially characterized were subsequently found to have mutations in the gene encoding the nicotinic acetylcholine receptor (nAChR) subunit Dalpha6. Subsequently,...
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