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Knockin of the G275E mutation of the nicotinic acetylcholine receptor (nAChR) α6 confers high levels of resistance to spinosyns in Spodoptera exigua.

Insect science - 1 Apr 2022

Zuo Ya-Yun, Xue Yu-Xin, Wang Ze-Yu, Ren Xuan, Aioub Ahmed A A, Wu Yi-Dong, Yang Yi-Hua, Hu Zhao-Nong

Abstract excerpt

Spinosyns, including spinosad and spinetoram, act on the insect central nervous system, gradually paralyzing or destroying the target insect. Spinosad resistance is associated with loss-of-function mutations in the nicotinic acetylcholine receptor (nAChR) α6 subunit in a number of agricultural pests. Using gene editing, nAChR α6 has been verified as a target for spinosyns in five insect species. Recently, a point...

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PMID: 33998150
DOI: 10.1111/1744-7917.12922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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