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Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388.

Chemistry & biology - 25 Nov 2009

Palaniappan Nadaraj, Dhote Vidya, Ayers Sloan, Starosta Agata L, Wilson Daniel N, Reynolds Kevin A

Abstract excerpt

The antibacterial activity of hygromycin A (HA) arises from protein synthesis inhibition and is dependent upon a methylenedioxy bridged-aminocyclitol moiety. Selective gene deletions and chemical complementation in Streptomyces hygroscopicus NRRL 2388 showed that the hyg18 and hyg25 gene products, proposed to generate a myo-inositol intermediate, are dispensable for HA biosynthesis but contribute to antibiotic...

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PMID: 19942141
DOI: 10.1016/j.chembiol.2009.10.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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