Article
Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Nov 2009
Blasi Giuseppe, Lo Bianco Luciana, Taurisano Paolo, Gelao Barbara, Romano Raffaella, Fazio Leonardo, Papazacharias Apostolos, Di Giorgio Annabella, Caforio Grazia, Rampino Antonio, Masellis Rita, Papp Audrey, Ursini Gianluca, Sinibaldi Lorenzo, Popolizio Teresa, Sadee Wolfgang, Bertolino Alessandro
Abstract excerpt
Personality traits related to emotion processing are, at least in part, heritable and genetically determined. Dopamine D(2) receptor signaling is involved in modulation of emotional behavior and activity of associated brain regions such as the amygdala and the prefrontal cortex. An intronic single nucleotide polymorphism within the D(2) receptor gene (DRD2) (rs1076560, guanine > thymine or G > T) shifts splicing...
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