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Article

Functional fluorescent protein insertions in herpes simplex virus gB report on gB conformation before and after execution of membrane fusion.

PLoS pathogens - 1 Sept 2014

Gallagher John R, Atanasiu Doina, Saw Wan Ting, Paradisgarten Matthew J, Whitbeck J Charles, Eisenberg Roselyn J, Cohen Gary H

Abstract excerpt

Entry of herpes simplex virus (HSV) into a target cell requires complex interactions and conformational changes by viral glycoproteins gD, gH/gL, and gB. During viral entry, gB transitions from a prefusion to a postfusion conformation, driving fusion of the viral envelope with the host cell membrane. While the structure of postfusion gB is known, the prefusion conformation of gB remains elusive. As the prefusion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25233449
DOI: 10.1371/journal.ppat.1004373
PMCID: PMC4169481

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CFP

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