Article
Mutations in Sensor 1 and Walker B in the bovine papillomavirus E1 initiator protein mimic the nucleotide-bound state.
Journal of virology - 1 Feb 2010
Liu Xiaofei, Stenlund Arne
Abstract excerpt
Viral replication initiator proteins are multifunctional proteins that utilize ATP binding and hydrolysis by their AAA+ modules for multiple functions in the replication of their viral genomes. These proteins are therefore of particular interest for understanding how AAA+ proteins carry out multiple ATP driven functions. We have performed a comprehensive mutational analysis of the residues involved in ATP binding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
