Article
Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.
PloS one - 1 Jan 2013
Larocca Rafael Assumpção, Moraes-Vieira Pedro Manoel, Bassi Enio José, Semedo Patrícia, de Almeida Danilo Candido, da Silva Marina Burgos, Thornley Thomas, Pacheco-Silva Alvaro, Câmara Niels Olsen Saraiva
Abstract excerpt
Adipose tissue-derived mesenchymal stem cells (ADSC) exhibit immunosuppressive capabilities both in vitro and in vivo. Their use for therapy in the transplant field is attractive as they could render the use of immunosuppressive drugs unnecessary. The aim of this study was to investigate the effect of ADSC therapy on prolonging skin allograft survival. Animals that were treated with a single injection of donor...
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