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Article

Synergy between bacterial infection and genetic predisposition in intestinal dysplasia.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2009

Apidianakis Yiorgos, Pitsouli Chrysoula, Perrimon Norbert, Rahme Laurence

Abstract excerpt

Accumulating evidence suggests that hyperproliferating intestinal stem cells (SCs) and progenitors drive cancer initiation, maintenance, and metastasis. In addition, chronic inflammation and infection have been increasingly recognized for their roles in cancer. Nevertheless, the mechanisms by which bacterial infections can initiate SC-mediated tumorigenesis remain elusive. Using a Drosophila model of gut...

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Identifiers

PMID: 19934041
DOI: 10.1073/pnas.0911797106
PMCID: PMC2791635

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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