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Article

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence.

Nature communications - 27 Jul 2015

Bou Sleiman Maroun S, Osman Dani, Massouras Andreas, Hoffmann Ary A, Lemaitre Bruno, Deplancke Bart

Abstract excerpt

Gut immunocompetence involves immune, stress and regenerative processes. To investigate the determinants underlying inter-individual variation in gut immunocompetence, we perform enteric infection of 140 Drosophila lines with the entomopathogenic bacterium Pseudomonas entomophila and observe extensive variation in survival. Using genome-wide association analysis, we identify several novel immune modulators....

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PMID: 26213329
DOI: 10.1038/ncomms8829
PMCID: PMC4525169

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