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Article

Requirement of arsenic biomethylation for oxidative DNA damage.

Journal of the National Cancer Institute - 16 Dec 2009

Kojima Chikara, Ramirez Dario C, Tokar Erik J, Himeno Seiichiro, Drobná Zuzana, Stýblo Miroslav, Mason Ronald P, Waalkes Michael P

Abstract excerpt

BACKGROUND: Inorganic arsenic is an environmental carcinogen that may act through multiple mechanisms including formation of methylated derivatives in vivo. Sodium arsenite (up to 5.0 microM) renders arsenic methylation-competent TRL1215 rat liver epithelial cells tumorigenic in nude mice at 18 w...

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Identifiers

PMID: 19933942
DOI: 10.1093/jnci/djp414
PMCID: PMC2794302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19933942-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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