Article
Oncogenomic disruptions in arsenic-induced carcinogenesis.
Oncotarget - 11 Apr 2017
Sage Adam P, Minatel Brenda C, Ng Kevin W, Stewart Greg L, Dummer Trevor J B, Lam Wan L, Martinez Victor D
Abstract excerpt
Chronic exposure to arsenic affects more than 200 million people worldwide, and has been associated with many adverse health effects, including cancer in several organs. There is accumulating evidence that arsenic biotransformation, a step in the elimination of arsenic from the human body, can induce changes at a genetic and epigenetic level, leading to carcinogenesis. At the genetic level, arsenic interferes...
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