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Article

Arsenic-Transformed Malignant Prostate Epithelia Can Convert Noncontiguous Normal Stem Cells into an Oncogenic Phenotype

4 Apr 2012

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) are likely critical to carcinogenesis, and, like normal stem cells (NSCs), are affected by microenvironmental factors. Malignant cells release extracellular factors, modifying tumor behavior. Inorganic arsenic, a human carcinogen, is associated with an overproduction of CSCs in various model systems of carcinogenesis. OBJECTIVE: We aimed to determine if NSCs are influenced by...

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PMID: 22472196
DOI: 10.1289/ehp.1204987

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