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Article

Targeted deletion of the zebrafish obscurin A RhoGEF domain affects heart, skeletal muscle and brain development.

Developmental biology - 15 Jan 2010

Raeker Maide O, Bieniek Ashley N, Ryan Alison S, Tsai Huai-Jen, Zahn Katelin M, Russell Mark W

Abstract excerpt

Obscurin is a giant structural and signaling protein that participates in the assembly and structural integrity of striated myofibrils. Previous work has examined the physical interactions between obscurin and other cytoskeletal elements but its in vivo role in cell signaling, including the functions of its RhoGTPase Exchange Factor (RhoGEF) domain have not been characterized. In this study, morpholino antisense...

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Identifiers

PMID: 19931525
DOI: 10.1016/j.ydbio.2009.11.018
PMCID: PMC2819229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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