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Article

Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity

18 Feb 2013

Abstract excerpt

Obscurin is a large myofibrillar protein that contains several interacting modules, one of which mediates binding to muscle-specific ankyrins. Interaction between obscurin and the muscle-specific ankyrin sAnk1.5 regulates the organization of the sarcoplasmic reticulum in striated muscles. Additional muscle-specific ankyrin isoforms, ankB and ankG, are localized at the subsarcolemma level, at which they contribute...

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PMID: 23420875
DOI: 10.1083/jcb.201205118

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