Article
An insertion/deletion polymorphism in the 3' untranslated region of beta-transducin repeat-containing protein (betaTrCP) is associated with susceptibility for hepatocellular carcinoma in Chinese.
Biochemical and biophysical research communications - 1 Jan 2010
Chen Shougong, He Yan, Ding Jun, Jiang Yuting, Jia Shasha, Xia Wei, Zhao Ji, Lu Man, Gu Zhenyong, Gao Yuzhen
Abstract excerpt
Hepatocellular carcinoma (HCC) is an epithelial cancer which originates from hepatocytes or their progenitors. As a positive regulator of NFkappaB signaling pathway, beta-transducin repeat-containing protein (betaTrCP) is overexpressed and oncogenic in epithelial cancers, suggesting a potential role of betaTrCP in HCC susceptibility. We carried out a case-control study in a Chinese population (256 cases and 367...
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