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Genetic Polymorphisms of TP53 and ApoB Genes and Risk of Biliary Tract Cancer: A Case-Cohort Study in Japan.

Cancer prevention research (Philadelphia, Pa.) - 2 Sept 2025

Asai Takao, Yamaji Taiki, Nakano Shiori, Sawada Norie, Inoue Manami, Tsugane Shoichiro, Tsuchiya Yasuo, Ikoma Toshikazu, Nakamura Kazutoshi, Iwasaki Motoki

Abstract excerpt

Although several retrospective studies have investigated the association of TP53 rs1042522 and ApoB rs693 with the risk of biliary tract cancer (BTC), results have been inconsistent. In this study, to provide evidence from a prospective study, we analyzed the association of these two genetic polymorphisms with BTC risk using data from the Japan Public Health Center-based Prospective Study. We conducted a...

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PMID: 40312921
DOI: 10.1158/1940-6207.CAPR-24-0536

Genes

BTC
TP53

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