Article
A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.
American journal of respiratory and critical care medicine - 15 Feb 2010
Sharma Sunita, Tantisira Kelan, Carey Vincent, Murphy Amy J, Lasky-Su Jessica, Celedón Juan C, Lazarus Ross, Klanderman Barbara, Rogers Angela, Soto-Quirós Manuel, Avila Lydiana, Mariani Thomas, Gaedigk Roger, Leeder Stephen, Torday John, Warburton David, Raby Benjamin, Weiss Scott T
Abstract excerpt
RATIONALE: Animal models demonstrate that aberrant gene expression in utero can result in abnormal pulmonary phenotypes. OBJECTIVES: We sought to identify genes that are differentially expressed during in utero airway development and test the hypothesis that variants in these genes influence lung function in patients with asthma. METHODS: Stage 1 (Gene Expression): Differential gene expression analysis across the...
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