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Article

Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts

15 Mar 2021

Abstract excerpt

Both canonical and non-canonical Wnt signaling pathway alterations have been documented in pulmonary disease pathogenesis and progression; therefore, they can be an attractive target for pharmaceutical management of severe asthma. Wnt/β-catenin signaling was shown to link early embryonic lung development impairment to later in life asthmatic airway remodeling. Here we explored the changes in Wnt signaling...

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PMID: 33791298
DOI: 10.3389/fcell.2021.641404

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