Article
Characterization of YopT effects on Rho GTPases in Yersinia enterocolitica-infected cells.
The Journal of biological chemistry - 29 Aug 2003
Aepfelbacher Martin, Trasak Claudia, Wilharm Gottfried, Wiedemann Agnès, Trulzsch Konrad, Krauss Kristina, Gierschik Peter, Heesemann Jurgen
Abstract excerpt
Pathogenic yersiniae employ a type III secretion system for translocating up to six effector proteins (Yersinia outer proteins (Yops)) into eukaryotic target cells. YopT is a cysteine protease that was shown to remove the C-terminal isoprenoid group of RhoA, Rac, and CDC42Hs. Here we characterized the cell biological and biochemical activities of YopT in cells infected with pathogenic Yersinia enterocolitica....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.