Article
Disruption of mitochondrial DNA replication in Drosophila increases mitochondrial fast axonal transport in vivo.
PloS one - 17 Nov 2009
Baqri Rehan M, Turner Brittany A, Rheuben Mary B, Hammond Bradley D, Kaguni Laurie S, Miller Kyle E
Abstract excerpt
Mutations in mitochondrial DNA polymerase (pol gamma) cause several progressive human diseases including Parkinson's disease, Alper's syndrome, and progressive external ophthalmoplegia. At the cellular level, disruption of pol gamma leads to depletion of mtDNA, disrupts the mitochondrial respiratory chain, and increases susceptibility to oxidative stress. Although recent studies have intensified focus on the role...
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