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Article

A Drosophila model of the neurological symptoms in Mpv17-related diseases.

Scientific reports - 31 Dec 2022

Kodani Atsushi, Yamaguchi Mizuki, Itoh Ririka, Huynh Man Anh, Yoshida Hideki

Abstract excerpt

Mutations in the Mpv17 gene are responsible for MPV17-related hepatocerebral mitochondrial DNA depletion syndrome and Charcot-Marie-Tooth (CMT) disease. Although several models including mouse, zebrafish, and cultured human cells, have been developed, the models do not show any neurological defects, which are often observed in patients. Therefore, we knocked down CG11077 (Drosophila Mpv17; dMpv17), an ortholog of...

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Identifiers

PMID: 36587049
DOI: 10.1038/s41598-022-27329-x
PMCID: PMC9805426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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