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Article

The combination of 5-fluorouracil plus p53 pathway restoration is associated with depletion of p53-deficient or mutant p53-expressing putative colon cancer stem cells.

Cancer biology & therapy - 1 Nov 2009

Huang Catherine, Zhang Xiang M, Tavaluc Raluca T, Hart Lori S, Dicker David T, Wang Wenge, El-Deiry Wafik S

Abstract excerpt

The cancer stem cell hypothesis suggests that rare populations of tumor-initiating cells may be resistant to therapy, lead to tumor relapse and contribute to poor prognosis for cancer patients. We previously demonstrated the feasibility of p53 pathway restoration in p53-deficient tumor cell popul...

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Source

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Identifiers

PMID: 19923910
DOI: 10.4161/cbt.8.22.10446
PMCID: PMC4541801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19923910-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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