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Article

Targeting p53-dependent stem cell loss for intestinal chemoprotection

7 Feb 2018

Abstract excerpt

KO or a small-molecule PUMA inhibitor (PUMAi) prevents perturbation of the stem cell niche, rapid activation of WNT and NOTCH signaling, and stem cell exhaustion during repeated exposures. PUMAi also protects human and mouse colonic organoids against chemotherapy-induced apoptosis and damage but does not protect cancer cells in vitro or in vivo. Therefore, targeting PUMA is a promising strategy for normal...

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PMID: 29437148
DOI: 10.1126/scitranslmed.aam7610

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