Article
Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.
Nature - 31 Jan 1991
Broek D, Bartlett R, Crawford K, Nurse P
Abstract excerpt
Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.
Topics
- CDC2 Protein Kinase
- Cell Cycle
- DNA Replication
- Fungal Proteins
- Mitosis
- Mutation
- Nitrogen
- S Phase
- Schizosaccharomyces