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Article

Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.

Nature - 31 Jan 1991

Broek D, Bartlett R, Crawford K, Nurse P

Abstract excerpt

Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.

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Identifiers

PMID: 1992340
DOI: 10.1038/349388a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Involvement of p34cdc2 in establishing the dependency of S phase on mitosis.PMID 1992340Read ↗

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.Semantic proximity Read ↗

Dominant mutants identify new roles for p34cdc2 in mitosis.Semantic proximity Read ↗

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The function of the chicken p34CDC2 protein kinase in fission yeast is cold sensitive for cell cycle progression through the G1 phase and temperature sensitive for traversal of mitosis.Semantic proximity Read ↗

Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae.Semantic proximity Read ↗

Isolation, characterisation and molecular cloning of new mutant alleles of the fission yeast p34cdc2+ protein kinase gene: identification of temperature-sensitive G2-arresting alleles.Semantic proximity Read ↗

Consequences of abnormal CDK activity in S phase.Semantic proximity Read ↗

Analysis of the Functionality of the Mitotic Checkpoints.Semantic proximity Read ↗

Cold-sensitive mutants of p34cdc2 that suppress a mitotic catastrophe phenotype in fission yeast.Semantic proximity Read ↗

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Identification of residues in fission yeast and human p34cdc2 required for S-M checkpoint control.Semantic proximity Read ↗

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