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Article

CFTR is essential for sperm fertilizing capacity and is correlated with sperm quality in humans

18 Nov 2009

Abstract excerpt

BACKGROUND: Our previous studies have demonstrated the cystic fibrosis transmembrane conductance regulator (CFTR) is important for capacitation and male fertility in mouse and guinea pig spermatozoa. However, the exact function of CFTR on human sperm fertilizing capacity, and correlation with sperm quality has not been established. The present study may shed light on some unexplained male infertility, and on a...

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PMID: 19923167
DOI: 10.1093/humrep/dep406

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