Article
CFTR Regulation of Aquaporin-Mediated Water Transport: A Target in Male Fertility.
Current drug targets - 1 Jan 2015
Alves Marco G, Sá Rosália, Jesus Tito T, Sousa Mário, Oliveira Pedro F
Abstract excerpt
The formation of competent spermatozoa is associated with the movement of large quantities of water and electrolytes in the various tissues and luminal fluids of the male reproductive tract. The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) and HCO3(-) membrane transporter. CFTR gene mutations cause cystic fibrosis (CF), the most common lethal genetic disease in Caucasians....
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