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Article

Essential Role of CFTR in PKA‐Dependent Phosphorylation, Alkalinization, and Hyperpolarization During Human Sperm Capacitation

13 Oct 2016

Abstract excerpt

Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation. It is well established that HCO3− is essential for capacitation because it activates the atypical soluble adenylate cyclase ADCY10 leading to cAMP production, and promotes alkalinization of cytoplasm, and membrane hyperpolarization. However, how HCO3− is...

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PMID: 27714810
DOI: 10.1002/jcp.25634

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