Article
Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2007
Xu Wen Ming, Shi Qi Xian, Chen Wen Ying, Zhou Chen Xi, Ni Ya, Rowlands Dewi Kenneth, Yi Liu Guo, Zhu Hu, Ma Ze Gang, Wang Xiao Fei, Chen Zhang Hui, Zhou Si Chang, Dong Hong Shan, Zhang Xiao Hu, Chung Yiu Wa, Yuan Yu Ying, Yang Wan Xi, Chan Hsiao Chang
Abstract excerpt
Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel, mutations of which cause cystic fibrosis, a disease characterized by defective Cl(-) and HCO(3)(-) transport. Although >95% of all CF male patients are infertile because of congenital bilateral absence of the vas defe...
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