Article

Induced Proteinuria Enhances Adeno-Associated Virus Transduction of Renal Tubule Epithelial Cells After Intravenous Administration

2025-05-30

Abstract excerpt

A variety of genetic diseases of the kidney tubule are amenable to correction via gene therapy. However, gene delivery to renal tubule epithelial cells mediated by viral vectors via the blood is inefficient due to the permselectivity of the glomerular barrier. We hypothesized that effacement of podocyte foot processes would disrupt typical glomerular limitations on filtration and make renal tubule epithelial cells...

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Literature Corpus work: 41dbdb23-e5a0-56b5-9ee9-f4147f0eaacd
DOI: 10.1101/2025.05.28.656514

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