Article
The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome.
Molecular and cellular biology - 1 Nov 2004
Gao Fei, Maiti Sourindra, Sun Guizhi, Ordonez Nelson G, Udtha Malini, Deng Jian Min, Behringer Richard R, Huff Vicki
Abstract excerpt
Renal failure is a frequent and costly complication of many chronic diseases, including diabetes and hypertension. One common feature of renal failure is glomerulosclerosis, the pathobiology of which is unclear. To help elucidate this, we generated a mouse strain carrying the missense mutation Wt1 R394W, which predisposes humans to glomerulosclerosis and early-onset renal failure (Denys-Drash syndrome [DDS])....
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