Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells

16 Nov 2009

Abstract excerpt

Forkhead box P3 (FOXP3)(+)CD4(+)CD25(+) inducible regulatory T (iT reg) cells play an important role in immune tolerance and homeostasis. In this study, we show that the transforming growth factor-beta (TGF-beta) induces the expression of the Runt-related transcription factors RUNX1 and RUNX3 in CD4(+) T cells. This induction seems to be a prerequisite for the binding of RUNX1 and RUNX3 to three putative RUNX...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19917773
DOI: 10.1084/jem.20090596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cellsPMID 19917773Read ↗

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1.Semantic proximity Read ↗

Human T regulatory cells: on the way to cognition.Semantic proximity Read ↗

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.Semantic proximity Read ↗

Transcriptional regulation of <i>Foxp3</i> gene: Multiple signal pathways on the roadSemantic proximity Read ↗

Transcriptional control of regulatory T-cell differentiation.Semantic proximity Read ↗

Regulatory T cells and Foxp3.Semantic proximity Read ↗

Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans.Semantic proximity Read ↗

CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cellsSemantic proximity Read ↗

Molecular control of regulatory T cell development and function.Semantic proximity Read ↗

Forkhead box P3: the peacekeeper of the immune system.Semantic proximity Read ↗

Foxp3 occupancy and regulation of key target genes during T-cell stimulation.Semantic proximity Read ↗

Foxp3: a genetic foundation for regulatory T cell differentiation and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.