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Article

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.

Genetics - 1 Jan 1998

Helliwell S B, Howald I, Barbet N, Hall M N

Abstract excerpt

The Saccharomyces cerevisiae genes TOR1 and TOR2 encode phosphatidylinositol kinase homologs. TOR2 has two essential functions. One function overlaps with TOR1 and mediates protein synthesis and cell cycle progression. The second essential function of TOR2 is unique to TOR2 and mediates the cell-cycle-dependent organization of the actin cytoskeleton. We have isolated temperature-sensitive mutants that are...

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Identifiers

PMID: 9475724
DOI: 10.1093/genetics/148.1.99
PMCID: PMC1459785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.PMID 9475724Read ↗

TOR2 is required for organization of the actin cytoskeleton in yeast.Semantic proximity Read ↗

Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.Semantic proximity Read ↗

Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase.Semantic proximity Read ↗

Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.Semantic proximity Read ↗

Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling.Semantic proximity Read ↗

Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex.Semantic proximity Read ↗

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.Semantic proximity Read ↗

Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway.Semantic proximity Read ↗

Opposite Effects of Tor1 and Tor2 on Nitrogen Starvation Responses in Fission YeastSemantic proximity Read ↗

Structure-based engineering of Tor complexes uncovers different roles of two types of yeast TORC1sSemantic proximity Read ↗

The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.Semantic proximity Read ↗

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