Article
Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study.
BMC cancer - 16 Nov 2009
Lavender Nicole A, Benford Marnita L, VanCleave Tiva T, Brock Guy N, Kittles Rick A, Moore Jason H, Hein David W, Kidd La Creis R
Abstract excerpt
BACKGROUND: Polymorphisms in glutathione S-transferase (GST) genes may influence response to oxidative stress and modify prostate cancer (PCA) susceptibility. These enzymes generally detoxify endogenous and exogenous agents, but also participate in the activation and inactivation of oxidative metabolites that may contribute to PCA development. Genetic variations within selected GST genes may influence PCA risk...
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