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Article

GSTP1 rs1138272 Polymorphism Affects Prostate Cancer Risk.

Medicina (Kaunas, Lithuania) - 13 Mar 2020

Santric Veljko, Djokic Milica, Suvakov Sonja, Pljesa-Ercegovac Marija, Nikitovic Marina, Radic Tanja, Acimovic Miodrag, Stankovic Vesna, Bumbasirevic Uros, Milojevic Bogomir, Babic Uros, Dzamic Zoran, Simic Tatjana, Dragicevic Dejan, Savic-Radojevic Ana

Abstract excerpt

Background and Objectives: One of the most frequent genetic alterations reported to date in prostate cancer (PC) is aberrant methylation of glutathione transferase P1 (GSTP1). Taking into consideration the involvement of oxidative stress in PC pathogenesis and recent advances in scientific understanding of the role of GSTP1*Ala114Val rs1138272 polymorphism in carcinogenesis, we hypothesized that this...

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PMID: 32183092
DOI: 10.3390/medicina56030128
PMCID: PMC7143748

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